Rauwolfia Extract (Reserpine)

For best quality Bulk Reserpine from India, contact us at sales@rauwolfia.net

Introduction : Reserpine is a naturally occurring drug that has been used for centuries in ancient India. Reserpine is extracted from the root of Rauwolfia serpentina or Rauwolfia vomitoria, plants found in India and Africa. In traditional herbal medicine, the root was brewed as a tea and used in humans to treat hypertension, insanity, snakebite, and cholera. The purified alkaloid, reserpine, was isolated in 1952 and is considered the first modern drug for the treatment of hypertension. Reserpine was approved by the FDA in 1953. Reserpine was the first drug found to interfere with the human sympathetic nervous system, and it initiated the effective pharmacotherapeutic control of hypertension.

Manufacturing Process : To make Rauwolfia Extract the fresh Sarpagandha roots are collected, cleaned to remove the physical impurities, like adhered soil and dirt. Then the dried roots are grinded to make it powder form. After that it is extract by suitable extractor and aseptic packaging for the further storage and transportation.

Phytochemical : Reserpine

PHARMACODYNAMICS : Basically Reserpine is a anti-adrenergic drug. Reserpine is a Postganglionic sympathetic nerve terminal blocker. Reserpine impairs the storage of biogenic amines by interfering with an uptake mechanism. Results in depletion of norepinephrine, dopamine, and serotonin in both central and peripheral neurons. Reserpine reduces the cardiac output by negative inotropic effect and negative chronotropic effect. Similarly by reducing sympathetic activity to blood vessels, reserpine relaxes capacitance vessels and reduces total peripheral resistance.

PHARMACOKINETICS : Reserpine depletes stores of serotonin and norepinephrine in the brain, adrenal medulla, and other tissues, and reduces the reuptake of catecholamines by adrenergic nerve terminals. The drug binds tightly to catecholamine storage vesicles in the adrenergic neuron, eventually destroying these vesicles so that the terminals cannot concentrate or store norepinephrine or dopamine. The result of reserpine's effects on biogenic amines is sympathetic dysfunction, with a subsequent decrease in peripheral vascular resistance and a lowering of blood pressure often associated with bradycardia. Cardiac output, renal blood flow, and glomerular filtration rate are also decreased. After reserpine is discontinued, the synthesis of new vesicles can restore sympathetic function, but this can take several weeks. Additionally, reserpine-induced adrenergic blockade results in increased parasympathomimetic effects including increased gastric acid secretion, GI hypermotility, and miosis.

Uses of Reserpine :

• The chief use reserpine is as a sedative and hypnotic and for reducing blood pressure. This alkaloids stimulate the central nervous system. Reserpine is more suitable for cases of mild anxiety or patients of chronic mental illness.
  
  
• Veterinary Use On Horses : Reserpine is used as a long acting tranquilizer to sedate excitable or difficult horses that are on enforced rest.

Side Effects :

• G.I. disturbances
• Depression, nightmares, Parkinsonism.
• Bradicardia, hypotension
• Nasal congestion
• Weight gain, swollen ankles
• Galactorrohea and Hyperprolactinemia
• Decreased libido.
• Sensory disturbances.

For best quality Bulk Reserpine from India, contact us at sales@rauwolfia.net

Our Products Speciality :

• ISO 9000 certified manufacturing unit.
• Organic raw material through dedicated farmers and supplier of raw-material.
• cGMP, manufacturing and Good Lab Practice.
• Quality specification, with microbial level less than 300 CFU/g and free from yeast, mold and other contaminants.
• Free from any heavy metal Content.
• Only available in Bulk (minimum quantity 100 Kg).
• Customized and contract manufacturing as per customer requirement.